Ayuno y quimioterapia, juntos contra el cáncer de mama
Palabras clave:
ayuno, cáncer, mama, quimioterapia
Resumen
El ayuno se ha estudiado en combinación a la quimioterapia para el tratamiento del cáncer, ya que se ha demostrado su efecto terapéutico, y reducción de la toxicidad y eventos adversos. A lo largo de este artículo, abordamos este tema para comprender los efectos del ayuno y la dieta que imita el ayuno en pacientes con cáncer de mama. A pesar de tener una gran variedad de opciones terapéuticas contra el cáncer, en muchos casos no se logra una remisión completa. Se ha demostrado que períodos de restricción calórica, mediante ayuno o ciertas dietas, tienen un impacto positivo en la calidad de vida del paciente, ya que las células malignas están más sensibilizadas al tratamiento y se reducen los efectos adversos.
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Bauersfeld, S. P., Kessler, C. S., Wischnewsky, M., Jaensch, A., Steckhan, N., Stange, R., Kunz, B., Brückner, B., Sehouli, J., & Michalsen, A., The effects of shortterm fasting on quality of life and tolerance to chemotherapy in patients with breast and ovarian cancer: A randomized cross-over pilot study. BMC Cancer, 18[1], pp.1–10, 2018. https://doi.org/10.1186/ s12885-018-4353-2
Brandhorst, S. Fasting and fasting-mimicking diets for chemotherapy augmentation. GeroScience, 43[3], pp.1201–1216, 2021. https://doi.org/10.1007/s11357-020-00317-7
De Groot, S., Lugtenberg, R. T., Cohen, D., Welters, M. J. P., Ehsan, I., Vreeswijk, M. P. G., Smit, V. T. H. B. M., de Graaf, H., Heijns, J. B., Portielje, J. E. A., van de Wouw, A. J., Imholz, A. L. T., Kessels, L. W., Vrijaldenhoven, S., Baars, A., Kranenbarg, E. M. K., Carpentier, M. D. de, Putter, H., van der Hoeven, J. J. M., … Kroep, J. R. Fasting mimicking diet as an adjunct to neoadjuvant chemotherapy for breast cancer in the multicentre randomized phase 2 DIRECT trial. Nature Communications, 11[1], pp. 1–9, 2020. https:// doi.org/10.1038/s41467-020-16138-3
De Groot, S., Pijl, H., Van Der Hoeven, J. J. M., & Kroep, J. R. Effects of shortterm fasting on cancer treatment. Journal of Experimental and Clinical Cancer Research, 38[1], pp.1–14, 2019. https://doi. org/10.1186/s13046-019-1189-9
Harbeck, N., & Gnant, M. Breast cancer. The Lancet, 389[10074], pp.1134–1150, 2017. https://doi.org/10.1016/S0140- 6736(16)31891-8
Horne, B. D., Muhlestein, J. B., & Anderson, J. L. Health effects of intermittent fasting: Hormesis or harm? A systematic review. American Journal of Clinical Nutrition, 102[2], pp. 464–470, 2015. https:// doi.org/10.3945/ajcn.115.109553
Merino Bonilla, J. A., Torres Tabanera, M., & Ros Mendoza, L. H. Breast cancer in the 21st century: from early detection to new therapies. Radiologia, 59[5], pp.368– 379, 2017. https://doi.org/10.1016/j. rx.2017.06.003
O’Flanagan, C. H., Smith, L. A., McDonell, S. B., & Hursting, S. D. When less may be more: Calorie restriction and response to cancer therapy. BMC Medicine, 15[1],pp. 1–9, 2017. https://doi.org/10.1186/s12916- 017-0873-x
Plotti, F., Terranova, C., Luvero, D., Bartolone, M., Messina, G., Feole, L., Cianci, S., Scaletta, G., Marchetti, C., Di Donato, V., Fagotti, A., Scambia, G., Benedetti Panici, P., & Angioli, R. Diet and Chemotherapy: The Effects of Fasting and Ketogenic Diet on Cancer Treatment. Chemotherapy, 65[3–4],pp. 77–84, 2020. https://doi. Org/10.1159/000510839
Raffaghello, L., Lee, C., Safdie, F. M., Wei, M., Madia, F., Bianchi, G., & Longo, V. D. Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy. Proceedings of the National Academy of Sciences of the United States of America, 105[24], pp.8215–8220, 2008. https://doi. org/10.1073/pnas.0708100105
Wei, M., Brandhorst, S., Shelehchi, M., Mirzaei, H., Cheng, C. W., Budniak, J., Groshen, S., Mack, W. J., Guen, E., Di Biase, S., Cohen, P., Morgan, T. E., Dorff, T., Hong, K., Michalsen, A., Laviano, A., & Longo, V. D. Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease. Science Translational Medicine, 9[377], pp.1- 12, 2017. https://doi.org/10.1126/scitranslmed.aai8700
Brandhorst, S. Fasting and fasting-mimicking diets for chemotherapy augmentation. GeroScience, 43[3], pp.1201–1216, 2021. https://doi.org/10.1007/s11357-020-00317-7
De Groot, S., Lugtenberg, R. T., Cohen, D., Welters, M. J. P., Ehsan, I., Vreeswijk, M. P. G., Smit, V. T. H. B. M., de Graaf, H., Heijns, J. B., Portielje, J. E. A., van de Wouw, A. J., Imholz, A. L. T., Kessels, L. W., Vrijaldenhoven, S., Baars, A., Kranenbarg, E. M. K., Carpentier, M. D. de, Putter, H., van der Hoeven, J. J. M., … Kroep, J. R. Fasting mimicking diet as an adjunct to neoadjuvant chemotherapy for breast cancer in the multicentre randomized phase 2 DIRECT trial. Nature Communications, 11[1], pp. 1–9, 2020. https:// doi.org/10.1038/s41467-020-16138-3
De Groot, S., Pijl, H., Van Der Hoeven, J. J. M., & Kroep, J. R. Effects of shortterm fasting on cancer treatment. Journal of Experimental and Clinical Cancer Research, 38[1], pp.1–14, 2019. https://doi. org/10.1186/s13046-019-1189-9
Harbeck, N., & Gnant, M. Breast cancer. The Lancet, 389[10074], pp.1134–1150, 2017. https://doi.org/10.1016/S0140- 6736(16)31891-8
Horne, B. D., Muhlestein, J. B., & Anderson, J. L. Health effects of intermittent fasting: Hormesis or harm? A systematic review. American Journal of Clinical Nutrition, 102[2], pp. 464–470, 2015. https:// doi.org/10.3945/ajcn.115.109553
Merino Bonilla, J. A., Torres Tabanera, M., & Ros Mendoza, L. H. Breast cancer in the 21st century: from early detection to new therapies. Radiologia, 59[5], pp.368– 379, 2017. https://doi.org/10.1016/j. rx.2017.06.003
O’Flanagan, C. H., Smith, L. A., McDonell, S. B., & Hursting, S. D. When less may be more: Calorie restriction and response to cancer therapy. BMC Medicine, 15[1],pp. 1–9, 2017. https://doi.org/10.1186/s12916- 017-0873-x
Plotti, F., Terranova, C., Luvero, D., Bartolone, M., Messina, G., Feole, L., Cianci, S., Scaletta, G., Marchetti, C., Di Donato, V., Fagotti, A., Scambia, G., Benedetti Panici, P., & Angioli, R. Diet and Chemotherapy: The Effects of Fasting and Ketogenic Diet on Cancer Treatment. Chemotherapy, 65[3–4],pp. 77–84, 2020. https://doi. Org/10.1159/000510839
Raffaghello, L., Lee, C., Safdie, F. M., Wei, M., Madia, F., Bianchi, G., & Longo, V. D. Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy. Proceedings of the National Academy of Sciences of the United States of America, 105[24], pp.8215–8220, 2008. https://doi. org/10.1073/pnas.0708100105
Wei, M., Brandhorst, S., Shelehchi, M., Mirzaei, H., Cheng, C. W., Budniak, J., Groshen, S., Mack, W. J., Guen, E., Di Biase, S., Cohen, P., Morgan, T. E., Dorff, T., Hong, K., Michalsen, A., Laviano, A., & Longo, V. D. Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease. Science Translational Medicine, 9[377], pp.1- 12, 2017. https://doi.org/10.1126/scitranslmed.aai8700
Publicado
2022-10-03
Cómo citar
Palomino-Pérez, M. J., Pacheco-Serrano, O. F., Durán-Castillo, C., María-Fernanda, M. F., Ibarra-Reynoso , L. del R., & Ruiz-Noa, Y. (2022). Ayuno y quimioterapia, juntos contra el cáncer de mama. Contactos, Revista De Educación En Ciencias E Ingeniería, 1(125), 35-42. Recuperado a partir de https://contactos.izt.uam.mx/index.php/contactos/article/view/222
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