Materiales compuestos por electrohilado para su uso en ingeniería de tejidos
Palabras clave:
Electrohilado, Biomateriales compuestos, Ingeniería de Tejidos
Resumen
En este trabajo se muestra el potencial que tiene la técnica de Electrohilado en la generación de andamios compuestos y en base a los parámetros de dicha técnica y las condiciones de la solución precursora utilizada, se tiene como resultado estructuras conformadas por fibras con diferentes diámetros y tamaños de poro, capaces de permitir el paso de células y nutrientes dentro del andamio, adecuado para permitir la adhesión y proliferación celular; se presenta la caracterización de estos andamios usando técnicas como Microscopía Electrónica de Barrido (MEB), Microscopía Raman, y mediante el análisis y la distribución de poro haciendo uso de programa de cómputo ImageJ.
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Citas
Jiyao Xing, Miao Zhang, Xinlin Liu, Chao Wang, Nannan Xu, Dongming Xing, Multi-material electrospinning: from methods to biomedical applications, Materials Today Bio, Volume 21, 2023, 100710, ISSN 2590-0064, https://doi.org/10.1016/j.mtbio.2023.100710.
Zulkifli, M.Z.A.; Nordin, D.; Shaari, N.; Kamarudin, S.K. Overview of Electrospinning for Tissue Engineering Applications. Polymers 2023, 15, 2418. https://doi.org/10.3390/polym15112418.
Yang, C.; Shao, Q.; Han, Y.; Liu, Q.; He, L.; Sun, Q.; Ruan, S. Fibers by Electrospinning and Their Emerging Applications in Bone Tissue Engineering. Appl. Sci. 2021, 11, 9082. https://doi.org/10.3390/app11199082.
Hadi Saniei, Sayedali Mousavi, Surface modification of PLA 3D-printed implants by electrospinning with enhanced bioactivity and cell affinity, Polymer, Volume 196, 2020,122467, ISSN 0032-3861, https://doi.org/10.1016/j.polymer.2020.122467.
Zhong H, Huang J, Wu J, et al. Electrospinning nanofibers to 1D, 2D, and 3D scaffolds and their biomedical applications. Nano Research, 2022, 15(2): 787-804. https://doi.org/10.1007/s12274-021-3593-7
Shi, Shuo & Si, Yifan & Han, Yanting & Iqbal, Mohammad Irfan & Fei, Bin & Li, Robert & Hu, Jinlian & Qu, Jinping. (2022). Recent Progress in Protective Membranes Fabricated Via Electrospinning: Advanced Materials, Biomimetic Structures, and Functional Applications. Advanced Materials. 34. 2107938. 10.1002/adma.202107938.
Flores-Sánchez María G., Atlántida M. Raya-Rivera, Diego R. Esquiliano-Rendon, Patricia G. Ontiveros-Nevares, Nancy C. Islas-Arteaga, Juan Morales-Corona & RobertoOlayo (2018) Scaffolds of polylactic acid/hydroxyapatite coated by plasma with polypyrrole-iodinefor the generation of neo-tissue–bone in vivo: Study in rabbit, International Journal of PolymericMaterials and Polymeric Biomaterials, 67:7, 427-437, DOI: 10.1080/00914037.2017.1342249.
Zahra Khalilimofrad, Hadi Baharifar, Azadeh Asefnejad, Kamyar Khoshnevisan, Collagen type I cross-linked to gelatin/chitosan electrospun mats: Application for skin tissue engineering, Materials Today Communications, Volume 35, 2023, 105889, ISSN 2352-4928, https://doi.org/10.1016/j.mtcomm.2023.105889.
Mohammad Hossein Mirmusavi, Mehdi Ahmadian, Saeed Karbasi, Polycaprolactone-chitosan/multi-walled carbon nanotube: A highly strengthened electrospun nanocomposite scaffold for cartilage tissue engineering, International Journal of Biological Macromolecules, Volume 209, Part B, 2022, Pages 1801-1814, ISSN 0141-8130, https://doi.org/10.1016/j.ijbiomac.2022.04.152.
Sun L, Gao W, Fu X, Shi M, Xie W, Zhang W, Zhao F, Chen X (2018) Enhanced wound healing in diabetic rats by nanofibrous scaffolds mimicking the Basketweave pattern of collagen fibrils in native skin. Biomater Sci 6:340–349. https://doi.org/10.1039/c7bm00545h.
Pal P, Srivas PK, Dadhich P, Das B, Maulik D, Dhara S (2017) Nano- /microfibrous cotton-wool-like 3D scaffold with core-shell architecture by emulsion electrospinning for skin tissue regeneration. ACS Biomater Sci Eng 3:3563–3575. https://doi.org/10.1021/acsbiomaterials.7b00681
Chen S, Wang H, Su Y, John JV, McCarthy A, Wong SL, Xie J (2020) Mesenchymal stem cell-laden, personalized 3D scaffolds with controlled structure and fiber alignment promote diabetic wound healing. Acta Biomater 108:153–167. https://doi.org/10.1016/j.actbio.2020.03.035
Villarreal-Gómez, L.J.; Pérez-González, G.L.; Bogdanchikova, N.; Pestryakov, A.; Nimaev, V.; Soloveva, A.; Cornejo-Bravo, J.M.; Toledaño-Magaña, Y. Antimicrobial Effect of Electrospun Nanofibers Loaded with Silver Nanoparticles: Influence of Ag Incorporation Method. J. Nanomater. 2021, 2021, 9920755.
Chung C. and Burdick J. A., Engineering cartilage tissue, Advanced Drug Delivery Reviews. (2008) 60, no. 2, 243–262, https://doi.org/10.1016/j.addr.2007.08.027, 2-s2.0-36849028030, 17976858.
Irawan V., Sung T. C., Higuchi A., and Ikoma T., Collagen scaffolds in cartilage tissue engineering and relevant approaches for future development, Tissue engineering and regenerative medicine. (2018) 15, no. 6, 673–697, https://doi.org/10.1007/s13770-018-0135-9, 2-s2.0-85057026834, 30603588.
Wise J. K., Yarin A. L., Megaridis C. M., and Cho M., Chondrogenic differentiation of human mesenchymal stem cells on oriented nanofibrous scaffolds: engineering the superficial zone of articular cartilage, Tissue Engineering Part A. (2009) 15, no. 4, 913–921, https://doi.org/10.1089/ten.tea.2008.0109, 2-s2.0 67049167743, 18767972.
Yan, B., Zhang, Y., Li, Z. et al. Electrospun nanofibrous membrane for biomedical application. SN Appl. Sci. 4, 172 (2022). https://doi.org/10.1007/s42452-022-05056-2.
Zulkifli, M.Z.A.; Nordin, D.; Shaari, N.; Kamarudin, S.K. Overview of Electrospinning for Tissue Engineering Applications. Polymers 2023, 15, 2418. https://doi.org/10.3390/polym15112418.
Yang, C.; Shao, Q.; Han, Y.; Liu, Q.; He, L.; Sun, Q.; Ruan, S. Fibers by Electrospinning and Their Emerging Applications in Bone Tissue Engineering. Appl. Sci. 2021, 11, 9082. https://doi.org/10.3390/app11199082.
Hadi Saniei, Sayedali Mousavi, Surface modification of PLA 3D-printed implants by electrospinning with enhanced bioactivity and cell affinity, Polymer, Volume 196, 2020,122467, ISSN 0032-3861, https://doi.org/10.1016/j.polymer.2020.122467.
Zhong H, Huang J, Wu J, et al. Electrospinning nanofibers to 1D, 2D, and 3D scaffolds and their biomedical applications. Nano Research, 2022, 15(2): 787-804. https://doi.org/10.1007/s12274-021-3593-7
Shi, Shuo & Si, Yifan & Han, Yanting & Iqbal, Mohammad Irfan & Fei, Bin & Li, Robert & Hu, Jinlian & Qu, Jinping. (2022). Recent Progress in Protective Membranes Fabricated Via Electrospinning: Advanced Materials, Biomimetic Structures, and Functional Applications. Advanced Materials. 34. 2107938. 10.1002/adma.202107938.
Flores-Sánchez María G., Atlántida M. Raya-Rivera, Diego R. Esquiliano-Rendon, Patricia G. Ontiveros-Nevares, Nancy C. Islas-Arteaga, Juan Morales-Corona & RobertoOlayo (2018) Scaffolds of polylactic acid/hydroxyapatite coated by plasma with polypyrrole-iodinefor the generation of neo-tissue–bone in vivo: Study in rabbit, International Journal of PolymericMaterials and Polymeric Biomaterials, 67:7, 427-437, DOI: 10.1080/00914037.2017.1342249.
Zahra Khalilimofrad, Hadi Baharifar, Azadeh Asefnejad, Kamyar Khoshnevisan, Collagen type I cross-linked to gelatin/chitosan electrospun mats: Application for skin tissue engineering, Materials Today Communications, Volume 35, 2023, 105889, ISSN 2352-4928, https://doi.org/10.1016/j.mtcomm.2023.105889.
Mohammad Hossein Mirmusavi, Mehdi Ahmadian, Saeed Karbasi, Polycaprolactone-chitosan/multi-walled carbon nanotube: A highly strengthened electrospun nanocomposite scaffold for cartilage tissue engineering, International Journal of Biological Macromolecules, Volume 209, Part B, 2022, Pages 1801-1814, ISSN 0141-8130, https://doi.org/10.1016/j.ijbiomac.2022.04.152.
Sun L, Gao W, Fu X, Shi M, Xie W, Zhang W, Zhao F, Chen X (2018) Enhanced wound healing in diabetic rats by nanofibrous scaffolds mimicking the Basketweave pattern of collagen fibrils in native skin. Biomater Sci 6:340–349. https://doi.org/10.1039/c7bm00545h.
Pal P, Srivas PK, Dadhich P, Das B, Maulik D, Dhara S (2017) Nano- /microfibrous cotton-wool-like 3D scaffold with core-shell architecture by emulsion electrospinning for skin tissue regeneration. ACS Biomater Sci Eng 3:3563–3575. https://doi.org/10.1021/acsbiomaterials.7b00681
Chen S, Wang H, Su Y, John JV, McCarthy A, Wong SL, Xie J (2020) Mesenchymal stem cell-laden, personalized 3D scaffolds with controlled structure and fiber alignment promote diabetic wound healing. Acta Biomater 108:153–167. https://doi.org/10.1016/j.actbio.2020.03.035
Villarreal-Gómez, L.J.; Pérez-González, G.L.; Bogdanchikova, N.; Pestryakov, A.; Nimaev, V.; Soloveva, A.; Cornejo-Bravo, J.M.; Toledaño-Magaña, Y. Antimicrobial Effect of Electrospun Nanofibers Loaded with Silver Nanoparticles: Influence of Ag Incorporation Method. J. Nanomater. 2021, 2021, 9920755.
Chung C. and Burdick J. A., Engineering cartilage tissue, Advanced Drug Delivery Reviews. (2008) 60, no. 2, 243–262, https://doi.org/10.1016/j.addr.2007.08.027, 2-s2.0-36849028030, 17976858.
Irawan V., Sung T. C., Higuchi A., and Ikoma T., Collagen scaffolds in cartilage tissue engineering and relevant approaches for future development, Tissue engineering and regenerative medicine. (2018) 15, no. 6, 673–697, https://doi.org/10.1007/s13770-018-0135-9, 2-s2.0-85057026834, 30603588.
Wise J. K., Yarin A. L., Megaridis C. M., and Cho M., Chondrogenic differentiation of human mesenchymal stem cells on oriented nanofibrous scaffolds: engineering the superficial zone of articular cartilage, Tissue Engineering Part A. (2009) 15, no. 4, 913–921, https://doi.org/10.1089/ten.tea.2008.0109, 2-s2.0 67049167743, 18767972.
Yan, B., Zhang, Y., Li, Z. et al. Electrospun nanofibrous membrane for biomedical application. SN Appl. Sci. 4, 172 (2022). https://doi.org/10.1007/s42452-022-05056-2.
Publicado
2025-11-10
Cómo citar
Flores Sánchez, M. G., & Olayo González, R. (2025). Materiales compuestos por electrohilado para su uso en ingeniería de tejidos. Contactos, Revista De Educación En Ciencias E Ingeniería, (144), 34 - 45. Recuperado a partir de https://contactos.izt.uam.mx/index.php/contactos/article/view/622
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