Fármacos anticancerígenos: de la naturaleza a la práctica clínica
Keywords:
Vinblastine, vincristine, taxol, camptothecin
Abstract
Since there is no ideal cure for cancer of any type, this set of diseases is among the main causes of mortality around the world. However, the study of medicinal plants has played a transcendental role in its treatment, having led to the identification of bioactive molecules with new structures and mechanisms of action that provided the basis for the development of some important anticancer drugs widely used in combination with other chemotherapeutic agents. This article expounds on the history of the discovery of three compounds derived from natural products that led to anticancer drugs. They are the alkaloids of vinca, the taxanes, and the analogs of camptothecin.
Downloads
Download data is not yet available.
References
Balunas, M.J. y Kinghorn, A.D., Drug discovery from medicinal plants, Life Sci, 78 [5], pp. 431-441, 2005.
Bracher, F. y Tremmel, T., From lead to drug utilizing a Mannich reaction: the topotecan story, Arch. Pharm. (Weinheim), 350[7], pp.1-8, 2017.
Buyel, J.F., Plants as sources of natural and recombinant anti-cancer agents, Biotechnol Adv, 36[2], pp. 506-520, 2018.
Christensen, S.B., Natural products that changed society, Biomedicines, 9[5], pp. 472, 2021.
Cragg, G.M., Paclitaxel (Taxol®): a success story with valuable lessons for natural product drug discovery and development, Med Res Rev, 18[5], pp. 315–331, 1998.
Cragg, G.M. y Newman, D.J., Plants as a source of anti-cancer agents, J Ethnopharmacol,100[1-2], pp. 72-79, 2005.
Gallego-Jara, J., Lozano-Terol, G., Sola-Martínez, R. A., Cánovas-Díaz, M., y de Diego Puente, T., A compressive review about Taxol®: history and future challenges. Molecules, 25[24], pp. 5986, 2020.
Isah, T., Anticancer alkaloids from trees: development into drugs, Pharmacogn Rev, 10[20], pp. 90-99, 2016.
Khalifa, S.A.M., Elias, N., Farag, M.A., Chen, L., Saeed, A., Hegazy, M.F., Moustafa, M.S., Abd El-Wahed, A., Al-Mousawi, S.M., Musharraf, S.G., Chang, F.R., Iwasaki, A., Suenaga, K., Alajlani, M., G¨oransson, U. y El-Seedi, H.R., Marine natural products: a source of novel anticancer drugs, Mar Drugs, 17 [9], pp. 491, 2019.
Martino, E., Della Volpe, S., Terribile, E., Benetti, E., Sakaj, M., Centamore, A., Sala, A. y Collina, S., The long story of camptothecin: from traditional medicine to drugs, Bioorg Med Chem Lett, 27[4], pp.701-707, 2017.
Noble, R.L., The discovery of the vinca alkaloids-chemotherapeutic agents against cancer, Biochem Cell Biol, 68[12], pp.1344-1351, 1990.
Organización Mundial de la Salud. Cáncer. https://www.who.int/es/news-room/factsheets/ detail/cancer. Recuperado el 1 de julio de 2021.
Taher, Z.M., Agouillal, F., Lim, J.R., Marof, A, Q., Dailin, D.J., Nurjayadi, M., Razig, N.M., Gomaa, S.E. y El Enshasy, H., Anticancer molecules from Catharanthus roseus, Indonesian J Pharm, 30[3], pp. 147–156, 2019.
Wall, M.E., Camptothecin and taxol: discovery to clinic, John Wiley & Sons, Inc. Med Res Rev, 18 [5], pp. 299-314, 1998.
Wani, M.C. y Horwitz, S.B., Nature as a remarkable chemist: a personal story of the discovery and development of Taxol. Anticancer Drugs, 25[5], pp. 482-487, 2014.
Whalen, K., Lippincott Illustrated Reviews. Farmacología. Walters Kluwer, China, p. 474, 2019.
Bracher, F. y Tremmel, T., From lead to drug utilizing a Mannich reaction: the topotecan story, Arch. Pharm. (Weinheim), 350[7], pp.1-8, 2017.
Buyel, J.F., Plants as sources of natural and recombinant anti-cancer agents, Biotechnol Adv, 36[2], pp. 506-520, 2018.
Christensen, S.B., Natural products that changed society, Biomedicines, 9[5], pp. 472, 2021.
Cragg, G.M., Paclitaxel (Taxol®): a success story with valuable lessons for natural product drug discovery and development, Med Res Rev, 18[5], pp. 315–331, 1998.
Cragg, G.M. y Newman, D.J., Plants as a source of anti-cancer agents, J Ethnopharmacol,100[1-2], pp. 72-79, 2005.
Gallego-Jara, J., Lozano-Terol, G., Sola-Martínez, R. A., Cánovas-Díaz, M., y de Diego Puente, T., A compressive review about Taxol®: history and future challenges. Molecules, 25[24], pp. 5986, 2020.
Isah, T., Anticancer alkaloids from trees: development into drugs, Pharmacogn Rev, 10[20], pp. 90-99, 2016.
Khalifa, S.A.M., Elias, N., Farag, M.A., Chen, L., Saeed, A., Hegazy, M.F., Moustafa, M.S., Abd El-Wahed, A., Al-Mousawi, S.M., Musharraf, S.G., Chang, F.R., Iwasaki, A., Suenaga, K., Alajlani, M., G¨oransson, U. y El-Seedi, H.R., Marine natural products: a source of novel anticancer drugs, Mar Drugs, 17 [9], pp. 491, 2019.
Martino, E., Della Volpe, S., Terribile, E., Benetti, E., Sakaj, M., Centamore, A., Sala, A. y Collina, S., The long story of camptothecin: from traditional medicine to drugs, Bioorg Med Chem Lett, 27[4], pp.701-707, 2017.
Noble, R.L., The discovery of the vinca alkaloids-chemotherapeutic agents against cancer, Biochem Cell Biol, 68[12], pp.1344-1351, 1990.
Organización Mundial de la Salud. Cáncer. https://www.who.int/es/news-room/factsheets/ detail/cancer. Recuperado el 1 de julio de 2021.
Taher, Z.M., Agouillal, F., Lim, J.R., Marof, A, Q., Dailin, D.J., Nurjayadi, M., Razig, N.M., Gomaa, S.E. y El Enshasy, H., Anticancer molecules from Catharanthus roseus, Indonesian J Pharm, 30[3], pp. 147–156, 2019.
Wall, M.E., Camptothecin and taxol: discovery to clinic, John Wiley & Sons, Inc. Med Res Rev, 18 [5], pp. 299-314, 1998.
Wani, M.C. y Horwitz, S.B., Nature as a remarkable chemist: a personal story of the discovery and development of Taxol. Anticancer Drugs, 25[5], pp. 482-487, 2014.
Whalen, K., Lippincott Illustrated Reviews. Farmacología. Walters Kluwer, China, p. 474, 2019.
Published
2022-01-03
How to Cite
López Lorenzo, Y., Arrieta Valencia, J., & Sánchez Mendoza, M. E. (2022). Fármacos anticancerígenos: de la naturaleza a la práctica clínica. Contactos, Revista De Educación En Ciencias E Ingeniería, (122), 33-45. Retrieved from https://contactos.izt.uam.mx/index.php/contactos/article/view/154
Section
Artículos
