Polipirrol/lodo sintetizado por plasma
Una estrategia terapeutica en lesiones traumaticas de la médula espinal
Abstract
Traumatic spinal cord injury (TSCI) is a disabling condition that can cause paralysis, insensibility and permanent dysfunction from the site of injury to the lower body. This is due to a series of secondary events that can increase the original damage and halt axonal regeneration. Therapeutic methods used to preserve and restore neurological function have so far been unsuccessful, so multidisciplinary therapeutic strategies may need to be integrated to develop functional treatments. The use of biopolymers to promote axonal regrowth and neuronal connectivity and the use of physical rehabilitation therapies to maintain muscle and joint fitness are experimental strategies to restore neurological function after LTME. Plasma-synthesized polypyrrole-iodine (PPy/I) is known to be an amine-rich polymeric material, which favors its biocompatibility and its relationship with central nervous tissue. This study analyzes the effects of PPy/I in different models of LTME. It also analyzes its effects when used in conjunction with physical rehabilitation (PR).
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