APLICACIÓN DE LOS TARDÍGRADOS EN LA MEDICINA, UNA REVISIÓN
Keywords:
Tardigrades; medicine; cryptobiosis; proteins
Abstract
Tardigrades are microscopic animals known for their ability to enter cryptobiosis, a state in which they suspend their vital functions to survive extreme conditions. They achieve this state thanks to specialized proteins that provide protection. This article presents a review on the application of tardigrades in medicine, analyzing specialized proteins such as Dsup, which protects the DNA of certain tardigrade species against high levels of radiation. This has sparked interest in medical research. Potential applications are discussed, including the protection of human DNA from radiation and the treatment of human diseases such as cancer, as well as the preservation of biological material, offering new perspectives for medicine.
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References
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Hashimoto, T., Horikawa, D. D., Saito, Y., Kuwahara, H., Kozuka-Hata, H., Shin-i, T., Minakuchi, Y., Ohishi, K., Motoyama, A., Aizu, T., Enomoto, A., Kondo, K., Tanaka, S., Hara, Y., Koshikawa, S., Sagara, H., Miura, T., Yokobori, S., Miyagawa, K., Suzuki, Y., Kubo, T., Oyama, M., Kohara, Y., Fujiyama, A., Arakawa, K., Katayama, T., Toyoda, A. y Kunieda, T., Extremotolerant tardigrade genome and improved radiotolerance of human cultured cells by tardigrade-unique protein. Nat. Commun., 7[1]:12808, 2016. https://doi.org/10.1038/ncomms12808
Klomchitcharoen, S., Tangwattanasirikun, T., Gallup, S., Smerwong, N., Arunwiriyakit, P., Tachavises, P., Tangkijngamwong, J., Phatthanaanukun, P., Jirapanyalerd, B., Chattanupakorn, S., Rungpongvanich, V., Nangsue, N., Meemon, K., Wongtrakoonkate, P., Hongeng, S. y Wongsawat, Y., MINERVA: A CubeSat for demonstrating DNA damage mitigation against space radiation in C. elegans by using genetic modification., Heliyon, 8[8]:e10267, 2022. https://doi.org/10.1016/j.heliyon.2022.e10267
Lagos-Tobías, A. M., Daza, A., Sánchez, C., León, M. V., Caicedo, M., Londoño, M. y Quiroga, S. Ositos de agua: Phylum tardigrada, Infozoa, Bol. de Zool., [2], pp. 1-16, 2013.
Mayoral-Peña, Z., Piña-Vazquez, D. M., Gómez-Sánchez, M., Salazar-Olivo, L. A., Aguilar-Tipacamú, G., y Arellano-Carbajal, F., El nematodo Caenorhabditis elegans como modelo para evaluar el potencial antihelmíntico de extractos de plantas. Rev. Mex. de Cienc. Pecu., 8[3], pp. 279-289, 2017.
Mínguez-Toral, M., Cuevas-Zuviría, B., Garrido-Arandia, M. y Pacios, L.F., A computational structural study on the DNA-protecting role of the tardigrade-unique Dsup protein, Sci. Rep., 10[1]:13424, 2020. https://doi.org/10.1038/s41598-020-70431-1
Packebush, M.H. Sanchez-Martinez, S., Biswas, S., KC, S., Nguyen, K.H., Ramírez, J. F., Nicholson, V. y Boothby, T. C., Natural and engineered mediators of desiccation tolerance stabilize Human Blood Clotting Factor VIII in a dry state, Sci. Rep., 13[1]:4542, 2023. https://doi.org/10.1038/s41598-023-31586-9
Ricci, C., Riolo, G., Marzocchi, C., Brunetti, J., Pini, A., y Cantara, S., The tardigrade damage suppressor protein modulates transcription factor and DNA repair genes in human cells treated with hydroxyl radicals and UV-C, Biol., 10[10]:970, 2021. https://doi.org/10.3390/biology10100970
Rolsma, J.L., Darch, W., Higgins, N.C. y Morgan, J. T., The tardigrade-derived mitochondrial abundant heat soluble protein improves adipose-derived stem cell survival against representative stressors, Sci. Rep., 14:11834, 2024. https://doi.org/10.1038/s41598-024-62693-w
Shaba, E., Landi, C., Marzocchi, C., Vantaggiato, L., Bini, L., Ricci, C. y Cantara, S., Proteomics Reveals How the Tardigrade Damage Suppressor Protein Teaches Transfected Human Cells to SurvV-C Stress, Int. J. Mol. Sci., 24[14]:11463, 2023. https://doi.org/10.3390/ijms241411463
Published
2025-10-09
How to Cite
Sánchez Jiménez , Y., Dueñas Cedillo , A. R., & Guevara Chumacero , L. M. (2025). APLICACIÓN DE LOS TARDÍGRADOS EN LA MEDICINA, UNA REVISIÓN. Contactos, Revista De Educación En Ciencias E Ingeniería, (143), 44 - 55. Retrieved from https://contactos.izt.uam.mx/index.php/contactos/article/view/599
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Artículos
