HDAC
LAS GUARDIANAS SILENCIOSAS DE LA EXPRESIÓN GÉNICA
Keywords:
Acetylation, Epigenetics, Gene regulation, Gene expression
Abstract
Histone deacetylases (HDACs) are a group of enzymes that play a crucial role in regulating gene expression by modifying the structure of chromatin. They achieve this by removing acetyl groups from histone proteins, which are the proteins around which DNA is wrapped in the cell nucleus. This process is known as deacetylation. Their activity is tightly regulated, and their dysregulation can contribute to diseases, making them significant targets for therapeutic intervention.
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References
King, J., Patel, M., & Chandrasekaran, S. (2021). Metabolism, HDACs, and HDAC inhibitors: A systems biology perspective. Metabolites, 11(11), 792.
https://doi.org/10.3390/metabo11110792
Marks, P. A., & Xu, W. S. (2009). Histone deacetylase inhibitors: Potential in cancer therapy. Journal of Cellular Biochemistry, 107(4), 600-608.
https://doi.org/10.1002/jcb.22185
Yang, X.-J., & Seto, E. (2008). The Rpd3/Hda1 family of lysine deacetylases: From bacteria and yeast to mice and men. Nature Reviews Molecular Cell Biology, 9(3), 206-218.
https://doi.org/10.1038/nrm2346
West, A. C., & Johnstone, R. W. (2014). New and emerging HDAC inhibitors for cancer treatment. Journal of Clinical Investigation, 124(1), 30-39.
https://doi.org/10.1172/JCI69738
https://doi.org/10.3390/metabo11110792
Marks, P. A., & Xu, W. S. (2009). Histone deacetylase inhibitors: Potential in cancer therapy. Journal of Cellular Biochemistry, 107(4), 600-608.
https://doi.org/10.1002/jcb.22185
Yang, X.-J., & Seto, E. (2008). The Rpd3/Hda1 family of lysine deacetylases: From bacteria and yeast to mice and men. Nature Reviews Molecular Cell Biology, 9(3), 206-218.
https://doi.org/10.1038/nrm2346
West, A. C., & Johnstone, R. W. (2014). New and emerging HDAC inhibitors for cancer treatment. Journal of Clinical Investigation, 124(1), 30-39.
https://doi.org/10.1172/JCI69738
Published
2025-10-09
How to Cite
Lozano Espinosa, M., Cortés Santiago, A., & Pacio Castillo, M. (2025). HDAC: LAS GUARDIANAS SILENCIOSAS DE LA EXPRESIÓN GÉNICA. Contactos, Revista De Educación En Ciencias E Ingeniería, (143), 63 - 72. Retrieved from https://contactos.izt.uam.mx/index.php/contactos/article/view/601
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