Con azúcar y miel, hasta los fármacos saben bien
Palabras clave:
nanotransportadores, ciclodextrinas, fármacos, complejos de inclusión
Resumen
The rapid advancement in drug development, driven by cutting-edge technologies such as virtual screening and combinatorial chemistry, has led to the creation of many potent drugs. However, a common issue arises where many of these drugs have low solubility and bioavailability in the body, which can potentially affect their effectiveness. To address this challenge, the development of intelligent drug nanocarriers has become a major focus in scientific research for over half a century. Among the options, using natural nanotransporters like cyclodextrins has emerged as a simple and highly effective solution.
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Citas
Boczar D, Michalska K. Cyclodextrin Inclusion Complexes with Antibiotics and Antibacterial Agents as Drug-Delivery Systems—A Pharmaceutical Perspective. Pharmaceutics. 2022; 14(7):1389. ( https://www.mdpi.com/1999-4923/14/7/1389 )
Caira MR. Cyclodextrin Inclusion of Medicinal Compounds for Enhancement of their Physicochemical and Biopharmaceutical Properties. Curr Top Med Chem. 2019;19(25):2357-2370. (https://www.eurekaselect.com/article/101593 )
Cid-Samamed A, Rakmai J, Mejuto JC, Simal-Gandara J, Astray G. Cyclodextrins inclusion complex: Preparation methods, analytical techniques and food industry applications. Food Chem. 2022 Aug 1;384:132467. doi: 10.1016/j.foodchem.2022.132467 ( https://www.sciencedirect.com/science/article/pii/S0308814622004290 )
Diniz TC, Pinto TCC, Menezes PDP, Silva JC, Teles RBA, Ximenes RCC, Guimarães AG, Serafini MR, Araújo AAS, Quintans Júnior LJ, Almeida JRGDS. Cyclodextrins improving the physicochemical and pharmacological properties of antidepressant drugs: a patent review. Expert Opin Ther Pat. 2018 Jan;28(1):81-92. ( https://www.tandfonline.com/doi/full/10.1080/13543776.2017.1384816 )
Kali G, Haddadzadegan S, Bernkop-Schnürch A. Cyclodextrins and derivatives in drug delivery: New developments, relevant clinical trials, and advanced products. Carbohydr Polym. 2024 Jan 15;324:121500. doi: 10.1016/j.carbpol.2023.121500. ( https://www.sciencedirect.com/science/article/pii/S0144861723009657?via%3Dihub )
Miranda GM, Santos VORe, Bessa JR, Teles YCF, Yahouédéhou SCMA, Goncalves MS, Ribeiro-Filho J. Inclusion Complexes of Non-Steroidal Anti-Inflammatory Drugs with Cyclodextrins: A Systematic Review. Biomolecules. 2021; 11(3):361. doi.org/10.3390/biom11030361 ( https://www.mdpi.com/2218-273X/11/3/361 )
Morin-Crini, N., Lichtfouse, E., & Fourmentin, S. (2020). History of Cyclodextrins. In G. Crini, S. Fourmentin, & E. Lichtfouse (Eds.), The History of Cyclodextrins (pp. 1-93). Springer. ( https://link.springer.com/chapter/10.1007/978-3-030-49308-0_1 )
Ogawa N, Kaga M, Endo T, Nagase H, Furuishi T, Yamamoto H, Kawashima Y, Ueda H. Quetiapine free base complexed with cyclodextrins to improve solubility for parenteral use. Chem Pharm Bull (Tokyo). 2013;61(8):809-15. doi: 10.1248/cpb.c13-00157. ( https://www.jstage.jst.go.jp/article/cpb/61/8/61_c13-00157/_article )
Ono N, Miyamoto Y, Ishiguro T, Motoyama K, Hirayama F, Iohara D, Seo H, Tsuruta S, Arima H, Uekama K. Reduction of bitterness of antihistaminic drugs by complexation with β-cyclodextrins. J Pharm Sci. 2011 May;100(5):1935-43. doi: 10.1002/jps.22417. ( https://www.sciencedirect.com/science/article/abs/pii/S0022354915321687?via%3Dihub )
Poulson BG, Alsulami QA, Sharfalddin A, El Agammy EF, Mouffouk F, Emwas A-H, Jaremko L, Jaremko M. Cyclodextrins: Structural, Chemical, and Physical Properties, and Applications. Polysaccharides. 2022; 3(1):1-31. ( https://www.mdpi.com/2673-4176/3/1/1 )
Caira MR. Cyclodextrin Inclusion of Medicinal Compounds for Enhancement of their Physicochemical and Biopharmaceutical Properties. Curr Top Med Chem. 2019;19(25):2357-2370. (https://www.eurekaselect.com/article/101593 )
Cid-Samamed A, Rakmai J, Mejuto JC, Simal-Gandara J, Astray G. Cyclodextrins inclusion complex: Preparation methods, analytical techniques and food industry applications. Food Chem. 2022 Aug 1;384:132467. doi: 10.1016/j.foodchem.2022.132467 ( https://www.sciencedirect.com/science/article/pii/S0308814622004290 )
Diniz TC, Pinto TCC, Menezes PDP, Silva JC, Teles RBA, Ximenes RCC, Guimarães AG, Serafini MR, Araújo AAS, Quintans Júnior LJ, Almeida JRGDS. Cyclodextrins improving the physicochemical and pharmacological properties of antidepressant drugs: a patent review. Expert Opin Ther Pat. 2018 Jan;28(1):81-92. ( https://www.tandfonline.com/doi/full/10.1080/13543776.2017.1384816 )
Kali G, Haddadzadegan S, Bernkop-Schnürch A. Cyclodextrins and derivatives in drug delivery: New developments, relevant clinical trials, and advanced products. Carbohydr Polym. 2024 Jan 15;324:121500. doi: 10.1016/j.carbpol.2023.121500. ( https://www.sciencedirect.com/science/article/pii/S0144861723009657?via%3Dihub )
Miranda GM, Santos VORe, Bessa JR, Teles YCF, Yahouédéhou SCMA, Goncalves MS, Ribeiro-Filho J. Inclusion Complexes of Non-Steroidal Anti-Inflammatory Drugs with Cyclodextrins: A Systematic Review. Biomolecules. 2021; 11(3):361. doi.org/10.3390/biom11030361 ( https://www.mdpi.com/2218-273X/11/3/361 )
Morin-Crini, N., Lichtfouse, E., & Fourmentin, S. (2020). History of Cyclodextrins. In G. Crini, S. Fourmentin, & E. Lichtfouse (Eds.), The History of Cyclodextrins (pp. 1-93). Springer. ( https://link.springer.com/chapter/10.1007/978-3-030-49308-0_1 )
Ogawa N, Kaga M, Endo T, Nagase H, Furuishi T, Yamamoto H, Kawashima Y, Ueda H. Quetiapine free base complexed with cyclodextrins to improve solubility for parenteral use. Chem Pharm Bull (Tokyo). 2013;61(8):809-15. doi: 10.1248/cpb.c13-00157. ( https://www.jstage.jst.go.jp/article/cpb/61/8/61_c13-00157/_article )
Ono N, Miyamoto Y, Ishiguro T, Motoyama K, Hirayama F, Iohara D, Seo H, Tsuruta S, Arima H, Uekama K. Reduction of bitterness of antihistaminic drugs by complexation with β-cyclodextrins. J Pharm Sci. 2011 May;100(5):1935-43. doi: 10.1002/jps.22417. ( https://www.sciencedirect.com/science/article/abs/pii/S0022354915321687?via%3Dihub )
Poulson BG, Alsulami QA, Sharfalddin A, El Agammy EF, Mouffouk F, Emwas A-H, Jaremko L, Jaremko M. Cyclodextrins: Structural, Chemical, and Physical Properties, and Applications. Polysaccharides. 2022; 3(1):1-31. ( https://www.mdpi.com/2673-4176/3/1/1 )
Publicado
2025-04-09
Cómo citar
Tovar Anaya, D. O., Villarreal Ramírez, E., & Zubillaga Luna, R. A. (2025). Con azúcar y miel, hasta los fármacos saben bien. Contactos, Revista De Educación En Ciencias E Ingeniería, (141), 101 - 111. Recuperado a partir de https://contactos.izt.uam.mx/index.php/contactos/article/view/525
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