Sleeping or not sleeping ... is not a dilemma: Lack of sleep is the cause of obesity and diabetes
Abstract
In recent years, evidences have been accumulated showing that sleep loss induces obesity, diabetes, metabolic syndrome, glucose intolerance and / or insulin resistance. Sorne studies have mentioned that the lack of sleep causes the subjects to have a greater opportunity to eat, and that is the reason why these metabolic problems are caused. However, this text shows evidence, including from our lab, that sleep loss modifies the metabolism without correlation with a higher food intake. Rodents that were sleep restricted for 6 weeks showed glucose intolerance since the first week of sleep loss, however, an increase in food intake or changes in insulin concentration was not observed. The lack of sleep is a cause of obesity and diabetes that has not been fully recognized in our country or for the World Health Organization, this omission must be recognized to make public health strategies to prevent jobs and activities that promote chronic sleep restriction.
Downloads
References
Van Cauter El, Blackman ID, Roland D, Spire JP, Refetoff S, Polonsky KS. Modulation of glucose regulation and insulin secretion by circadian rhythmicity and sleep. J Clin Invest. 88:934-42. 1991.
Spiegel Kl, Leproult R, Van Cauter E. Impact of sleep debt on metabolic and endocrine function. Lancet. 354(9188):1435-9. 1999.
Knutson KL 1, Spiegel K, Penev P, Van Cauter E. The metabolic consequences of sleep deprivation. Sleep Med Rev.11 (3): 163-78. 2007
Gómez-González B 1, Domínguez-Salazar E, Hurtado-Alvarado G, Esqueda-Leon E, Santana-Miranda R, Rojas-Zamorano JA, Velázquez-Moctezuma J. Role of sleep in the regulation of the immune system and the pituitary hormones. Ann N Y Acad Sci1261 :97-106. 2012.
Di Milia L, Vandelanotte C, Duncan MJ. The association between short sleep and obesity after controlling for demographic, lifestyle, work and health related factors. Sleep Med. 14(4):319-23. 2013
Lou P, Zhang P, Zhang L, Chen P, Chang G, Zhang N, Li T, Qiao C. Effects ofsleep duration and sleep quality on prevalence of type 2 diabetes mellitus: A 5-year follow-up study in China. Diabetes Res Clin Pract. 109(1 ): 178-84. 2015.
Hurtado-Alvarado G, Becerril-Villanueva E, Contis-Montes de Oca A, Domínguez-Salazar E, Salinas-Jazmín N, Pérez-Tapia SM, Pavon L, Velázquez-Moctezuma J, Gómez-González B. Toe yin/yang of in:flammatory status: Bloodbrain barrier regulation during sleep. Brain Behavlmmun. 69:154-166. 2018.
