Reparación de la médula espinal
problemática y estrategias
Palabras clave:
Biomateriales; Neuroprotección; Neuroimagen; Ingeniería Tisular
Resumen
La lesión de médula espinal es un problema de salud pública que carece de tratamientos eficaces para conducir a la recuperación completa de los pacientes y por lo tanto múltiples líneas de investigación se nutren de fuentes de nueva información de manera prácticamente constante. Desde la complejidad de su problemática en el desarrollo natural del padecimiento, sus técnicas de análisis en constante actualización y las diversas propuestas de tratamiento desde múltiples enfoques tecnológicos, hoy en día contamos con una gran cantidad de información del contexto actual y las tendencias en estrategias para buscar la recuperación estructural y funcional de este tejido vital para la calidad de vida de las personas. En el presente trabajo abordamos parte de la problemática y las posibles soluciones propuestas.
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Alvi MA, Pedro KM, Quddusi AI, Fehlings MG. Advances and Challenges in Spinal Cord Injury Treatments. J Clin Med 2024;13:1– 24. https://doi.org/10.3390/jcm13144101.
Coyoy-Salgado A, Orozco-Barrios C, Sánchez- Torres S, Olayo MG, Cruz GJ, Morales- Corona J, et al. Gene expression and locomotor recovery in adult rats with spinal cord injury and plasma-synthesized polypyrrole/iodine application combined with a mixed rehabilitation scheme. Front Neurol 2023;14:1124245.
https://doi. org/10.3389/fneur.2023.1124245.
David G, Mohammadi S, Martin AR, Cohen- Adad J, Weiskopf N, Thompson A, et al. Traumatic and nontraumatic spinal cord injury: pathological insights from neuroimaging. Nat Rev Neurol 2019;15:718–31. https://doi.org/10.1038/s41582-019-0270-5.
Grijalva-Otero I, Doncel-Pérez E. Traumatic Human Spinal Cord Injury: Are Single Treatments Enough to Solve the Problem? Arch Med Res 2024;55. https://doi. org/10.1016/j.arcmed.2023.102935.
Heras-Romero Y, Morales-Guadarrama A, Santana-Martínez R, Ponce I, Rincón-Heredia R, Poot-Hernández AC, et al. Improved post-stroke spontaneous recovery by astrocytic extracellular vesicles. Mol Ther 2021;30:1–18. https://doi.org/10.1016/j. ymthe.2021.09.023.
Ishaque AH, Alvi MA, Pedro K, Fehlings MG. Imaging protocols for non-traumatic spinal cord injury: current state of the art and future directions. Expert Rev Neurother 2024;24:691–709. https://doi.org/10.1 080/14737175.2024.2363839. Islas-Arteaga NC, Raya Rivera A, Esquiliano Rendon DR, Morales-Corona J, Ontiveros- Nevares PG, Flores Sánchez MG, et al. Electrospun scaffolds with surfaces modified by plasma for regeneration of articular cartilage tissue: a pilot study in rabbit. Int J Polym Mater Polym Biomater 2019;68:1089–98. https://doi.org/10.1080/0 0914037.2018.1534109.
Li Y, Luo W, Meng C, Shi K, Gu R, Cui S. Exosomes as promising bioactive materials in the treatment of spinal cord injury. Stem Cell Res Ther 2024;15:335. https:// doi.org/10.1186/s13287-024-03952-5.
Osorio-Londoño D, Heras-Romero Y, Tovar-y-Romo LB, Olayo-González R, Morales-Guadarrama A. Improved Recovery of Complete Spinal Cord Transection by a Plasma-Modified Fibrillar Scaffold. Polymers (Basel) 2024;16. https://doi. org/10.3390/polym16081133.
Pedro KM, Alvi MA, Fehlings MG. Obstacles in “Time to Spine”: Challenges for the Timely Delivery of Acute Surgical Care for Patients with Traumatic and Non-Traumatic Spinal Cord Injury. Healthcare 2024;12:2222. https://doi.org/10.3390/ healthcare12222222.
Ralph PC, Choi SW, Baek MJ, Lee SJ. Regenerative medicine approaches for the treatment of spinal cord injuries: Progress and challenges. Acta Biomater 2024;189:57–72. https://doi.org/10.1016/j. actbio.2024.10.021.
Sánchez-Torres S, Díaz-Ruíz A, Ríos C, Olayo MG, Cruz GJ, Olayo R, et al. Recovery of motor function after traumatic spinal cord injury by using plasma-synthesized polypyrrole/iodine application in combination with a mixed rehabilitation scheme. J Mater Sci Mater Med 2020;31. https://doi. org/10.1007/s10856-020-06395-5.
Serratos IN, Olayo R, Millán-Pacheco C, Morales-Corona J, Vicente-Escobar JO, Soto-Estrada AM, et al. Modeling integrin and plasma-polymerized pyrrole interactions: chemical diversity relevance for cell regeneration. Sci Rep 2019;9:1–12. https:// doi.org/10.1038/s41598-019-43286-4.
Yang J, Jin H, Tang C, Liu L. Nanomaterials for the treatment of spinal cord injury. Appl Mater Today 2024;38:102193. https:// doi.org/10.1016/j.apmt.2024.102193.
Zeller SL, Stein A, Frid I, Carpenter AB, Soldozy S, Rawanduzy C, et al. Critical Care of Spinal Cord Injury. Curr Neurol Neurosci Rep 2024;24:355–63. https://doi. org/10.1007/s11910-024-01357-8.
Zhang N, Hu J, Liu W, Cai W, Xu Y, Wang X, et al. Advances in Novel Biomaterial-Based Strategies for Spinal Cord Injury Treatment. Mol Pharm 2024. https://doi. org/10.1021/acs.molpharmaceut.3c01104.
Coyoy-Salgado A, Orozco-Barrios C, Sánchez- Torres S, Olayo MG, Cruz GJ, Morales- Corona J, et al. Gene expression and locomotor recovery in adult rats with spinal cord injury and plasma-synthesized polypyrrole/iodine application combined with a mixed rehabilitation scheme. Front Neurol 2023;14:1124245.
https://doi. org/10.3389/fneur.2023.1124245.
David G, Mohammadi S, Martin AR, Cohen- Adad J, Weiskopf N, Thompson A, et al. Traumatic and nontraumatic spinal cord injury: pathological insights from neuroimaging. Nat Rev Neurol 2019;15:718–31. https://doi.org/10.1038/s41582-019-0270-5.
Grijalva-Otero I, Doncel-Pérez E. Traumatic Human Spinal Cord Injury: Are Single Treatments Enough to Solve the Problem? Arch Med Res 2024;55. https://doi. org/10.1016/j.arcmed.2023.102935.
Heras-Romero Y, Morales-Guadarrama A, Santana-Martínez R, Ponce I, Rincón-Heredia R, Poot-Hernández AC, et al. Improved post-stroke spontaneous recovery by astrocytic extracellular vesicles. Mol Ther 2021;30:1–18. https://doi.org/10.1016/j. ymthe.2021.09.023.
Ishaque AH, Alvi MA, Pedro K, Fehlings MG. Imaging protocols for non-traumatic spinal cord injury: current state of the art and future directions. Expert Rev Neurother 2024;24:691–709. https://doi.org/10.1 080/14737175.2024.2363839. Islas-Arteaga NC, Raya Rivera A, Esquiliano Rendon DR, Morales-Corona J, Ontiveros- Nevares PG, Flores Sánchez MG, et al. Electrospun scaffolds with surfaces modified by plasma for regeneration of articular cartilage tissue: a pilot study in rabbit. Int J Polym Mater Polym Biomater 2019;68:1089–98. https://doi.org/10.1080/0 0914037.2018.1534109.
Li Y, Luo W, Meng C, Shi K, Gu R, Cui S. Exosomes as promising bioactive materials in the treatment of spinal cord injury. Stem Cell Res Ther 2024;15:335. https:// doi.org/10.1186/s13287-024-03952-5.
Osorio-Londoño D, Heras-Romero Y, Tovar-y-Romo LB, Olayo-González R, Morales-Guadarrama A. Improved Recovery of Complete Spinal Cord Transection by a Plasma-Modified Fibrillar Scaffold. Polymers (Basel) 2024;16. https://doi. org/10.3390/polym16081133.
Pedro KM, Alvi MA, Fehlings MG. Obstacles in “Time to Spine”: Challenges for the Timely Delivery of Acute Surgical Care for Patients with Traumatic and Non-Traumatic Spinal Cord Injury. Healthcare 2024;12:2222. https://doi.org/10.3390/ healthcare12222222.
Ralph PC, Choi SW, Baek MJ, Lee SJ. Regenerative medicine approaches for the treatment of spinal cord injuries: Progress and challenges. Acta Biomater 2024;189:57–72. https://doi.org/10.1016/j. actbio.2024.10.021.
Sánchez-Torres S, Díaz-Ruíz A, Ríos C, Olayo MG, Cruz GJ, Olayo R, et al. Recovery of motor function after traumatic spinal cord injury by using plasma-synthesized polypyrrole/iodine application in combination with a mixed rehabilitation scheme. J Mater Sci Mater Med 2020;31. https://doi. org/10.1007/s10856-020-06395-5.
Serratos IN, Olayo R, Millán-Pacheco C, Morales-Corona J, Vicente-Escobar JO, Soto-Estrada AM, et al. Modeling integrin and plasma-polymerized pyrrole interactions: chemical diversity relevance for cell regeneration. Sci Rep 2019;9:1–12. https:// doi.org/10.1038/s41598-019-43286-4.
Yang J, Jin H, Tang C, Liu L. Nanomaterials for the treatment of spinal cord injury. Appl Mater Today 2024;38:102193. https:// doi.org/10.1016/j.apmt.2024.102193.
Zeller SL, Stein A, Frid I, Carpenter AB, Soldozy S, Rawanduzy C, et al. Critical Care of Spinal Cord Injury. Curr Neurol Neurosci Rep 2024;24:355–63. https://doi. org/10.1007/s11910-024-01357-8.
Zhang N, Hu J, Liu W, Cai W, Xu Y, Wang X, et al. Advances in Novel Biomaterial-Based Strategies for Spinal Cord Injury Treatment. Mol Pharm 2024. https://doi. org/10.1021/acs.molpharmaceut.3c01104.
Publicado
2025-04-02
Cómo citar
Osorio Londoño, D. M., Morales Guadarrama, A., Heras Romero, Y., Morales Corona, J., & Olayo González, R. (2025). Reparación de la médula espinal: problemática y estrategias. Contactos, Revista De Educación En Ciencias E Ingeniería, (140), 28 - 36. Recuperado a partir de https://contactos.izt.uam.mx/index.php/contactos/article/view/503
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